inquiry@rdetect.com 【Product Details】
Methadone is a potent opioid. It produces cross-dependence and tolerance with other opioids and can replace any of them. Due to the long half-life (the time it takes for the concentration of the drug in the blood to decrease by 50 per cent), the degree of withdrawal symptoms itself is less severe, which makes methadone the basis for substitution and detoxification treatment for opioid addiction. In comparison with other detoxification drugs, methadone has significant efficacy in controlling withdrawal symptoms and a high success rate in detoxification treatment; it can be taken orally, and a single dose of the drug can produce clinical effects for 24 hours; and it is safe to administer, with no serious side effects. Methadone has become the most commonly used drug for detoxification treatment. At present, methadone substitution tapering is one of the conventional detoxification methods for opioid addiction.
In recent years, there have been many cases of drug addicts taking methadone illegally in the coastal areas of China, especially those who originally took or injected heroin or Dulcolax, and took methadone substitution once the interruption of the drug supply resulted in strong withdrawal symptoms. Oral methadone can maintain its effect for more than 24 hours, but since its effect is weaker than that of heroin, these drug abusers will turn back to heroin as soon as they can regain access to it.
Methadone, as a special drug of the narcotic class, is a drug if it is in legal channels, but once it flows into channels outside state control, it is a narcotic. As with other drugs, methadone consumption produces euphoria and can be addictive. Once abused, it produces similar harms as other drugs.
The pharmacological effects of methadone are listed below:
1、The pharmacological effects of methadone are identical in nature to those of morphine. It is characterised by strong analgesic potency and is effective when taken orally. It is effective in the treatment of physical withdrawal symptoms in opioid addicts, with a long-lasting effect and effective in repeated applications. It is suitable for the drug treatment of opioid addicts.
2、Its sedative and respiratory inhibitory effects, as well as its effects on smooth muscle and cardiovascular system are similar to those of morphine, but weaker than morphine.
3、Methadone has a strong analgesic effect, its efficacy is two to three times that of morphine, and its analgesic effect is slower and lasts for a long time, which is suitable for chronic pain, and its effect on acute pain is a little worse. The hypnotic effect caused by a single dose is lighter than the equivalent dose of morphine, such as repeated application can cause obvious sedative effect. Methadone induces pupil dilation, cough suppressant effect and effect on pituitary hormones, which is the same as morphine in nature.
4、Methadone slows down gastrointestinal peristalsis, prolongs gastric emptying, increases the tension of intestinal smooth muscle at rest, and significantly reduces the propulsive activity of the rectum, which can lead to constipation. This is more common in methadone detoxification.
5、Methadone has a respiratory inhibitory effect on the foetus in pregnancy, so it is not suitable for obstetric analgesia.
【Precautions】
1、 this test card is only used for one-time in vitro diagnosis, the same test card shall not be reused.
2、this product is used for qualitative detection of drugs or their metabolites, only for the judicial and public security system for drug users of the initial screening test, not for family testing, not for clinical diagnosis or treatment, medical institutions, workplaces for human urine sample testing.
3、This product is suitable for testing human urine samples.
4、a large number of specimens for the test, please make a good mark, so as to avoid confusion.
5、the experimental environment should be protected from the wind, avoiding too high temperature, too high humidity or too dry environment for the experiment.
6、each urine sample should use a new collection container and pipette to avoid contamination.
7、Do not freeze or use after the expiration date.
8、Do not use if the inner package is damaged.
