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Cocaine, also known as cocaine, the first natural alkaloid (C17H21NO4) with local anaesthetic effect discovered by mankind, is a long-acting ester local anaesthetic, with high fat solubility, strong penetrating power and good affinity for nerve tissue. It can block human nerve conduction and produce local anaesthesia, and was widely used as an anaesthetic in the surgery of the five senses such as eyes, nose and throat in the early stage. Its vasoconstrictive effect may be related to blocking the reuptake of norepinephrine by nerve endings It can stimulate the cerebral cortex by enhancing the activity of chemical substances in the body, excites the central nervous system, and shows high emotion, mobility, talkativeness, and sometimes aggressive tendency, and has a strong addictive property.
Cocaine is commonly abused by drug abusers in the form of nasal inhalation, where it is absorbed through the nasal mucosa. The long-term effects of this method cause necrosis or ulceration of some of the tissues of the nasal mucosa; also because of the irritating effect of cocaine on the nasal mucosa, drug abusers often involuntarily pick their noses, resulting in perforation or even collapse of the nasal septum. When cocaine is injected intravenously, its toxic effects can reach the heart very rapidly, posing a very high risk to life. Drug abusers often use unsterilised syringes, which are highly susceptible to skin abscesses and various infections. Abusers can also contract and spread hepatitis and HIV as a result of sharing needles and syringes.
The euphoric effect of cocaine on the central nervous system is an important cause of abuse. In the early stages of euphoria, abusers experience euphoria, feel euphoric and comfortable, and behave in a smug and talkative manner. The euphoric effect of the drug produces a feeling of fatigue. This type of euphoria only lasts for about 30 minutes. Afterwards, the depressing effect it has on the body occurs. In order to recover the initial experience, drug users often use a second dose,……, or even every 10 minutes to maintain the “strength of the addiction” does not decline. Week after week, the dosage gets bigger and bigger, and the use becomes more and more frequent, bringing the addict to the abyss of destruction.
When the dose is increased, the heart rhythm increases, shortness of breath, vomiting, tremors, spasms and convulsions may occur. Addicts develop paranoid-like psychosis with delusions and pseudo-hallucinations. Hallucinations, hallucinations, the feeling of seeing things that do not actually appear, or the feeling that a part of the body has “worms” drilled into it in the surge of discomfort, and often “take measures” to self-mutilation of limbs. In large doses, it can lead to death. A single dose of 70 milligrams of pure cocaine can kill a person weighing 70 kilograms on the spot.
